CMEonHIV.com is dedicated to providing online CME presentations (slides with voiceover) on HIV/AIDS for healthcare professionals given by local and international experts to keep you up-to-date on the ongoing developments in the field.
Conference
"An Overview of Switch Maintenance" Pr. Christine Katlama (biography) English - 2003-11-28 - 45 minutes
(43 slides)
Summary : In order to promote long-term tolerability in patients having an undetectable viral load, there are several options, one of which is to switch the treatment to maintenance therapy with another treatment, when it is desired, for example to improve tolerability, metabolic abnormalities or adherence, and/or to simplify the regimen.
This presentation will look at several studies of switching therapy, and compare different regimens on the basis of potency, metabolic profile, tolerability, fat distribution, adherence, patient acceptability and quality of life.
Learning objectives : The participant will learn about the use of Switch-Maintenance therapy.
Conclusions:
-Switch-Maintenance has a definitive role in long-term therapy where the object of treatment is to maintain a virologically suppressive regimen in a context of a minimal toxicity.
-NNRTI and 3 Nuc regimens are simple and convenient therapies...one of the critical issues in long-term compliance.
-3 Nuc regimens may reduce adverse events (including lipid improvements);
-Not all 3 nuc regimens are similar in terms of efficacy. Past ARV history is a key issue to consider before switching patient.
-Long-term tolerance with specific attention to lipodystrophy syndrome should be investigated.
USER ACKNOWLEDGES AND AGREES THAT ALL DECISIONS MADE WITH THE ASSISTANCE OR USE OF THE SOFTWARE AND/OR THE WEBSITE AND/OR BASED ON CONTENT FOUND HEREIN WILL BE EXCLUSIVELY THE RESPONSIBILITY OF THE USER.
