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 Conference
"Cardiovascular Risk in HIV Positive Patients"
Dr. Marek Smieja (biography)
English - 2005-09-08 - 46 minutes
(47 slides)

Summary :
Several studies have associated HIV infection with an increased cardiovascular risk. In this presentation, Dr. Smieja addresses the possibility of HIV as a risk factor of cardiovascular disease in itself. As well, he looks at the effect of HIV treatment in predisposing a patient to increased cardiovascular risk.

Is HIV a risk factor for cardiovascular disease? It is important to identify the prevalence of common risk factors in HIV positive patients such as age, gender, cholesterol, diabetes, etc so as to determine whether it is the infection or other accompanying risk factors involved. Dr. Smieja reviews several studies looking specifically at common cardiovascular risk factors among HIV positive patients.

Is the HIV treatment a risk factor for cardiovascular disease? It is important to recognize that an increase in risk due to HIV treatment may not necessarily encourage the discontinuation of treatment. One must take into consideration that in doing so, most probably will exacerbate the infection leading to other more severe outcomes. Dr. Smieja presents studies on the incidence of cardiovascular events in patients on HAART therapy. He introduces several measuring techniques useful in identifying those at risk of cardiovascular disease. These include exercise stress testing, coronary angiography, coronary artery CT, brachial artery ultrasound, and carotid artery ultrasound.

Overall, Dr. Smieja delivers an in depth review of past and current studies on HIV infection and treatment in cardiovascular risk and concludes by stating future directions.

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Learning objectives :
After viewing this presentation, participants will be able to discuss:
- HIV infection as a risk factor for cardiovascular disease;
- HIV treatment as a risk factor for cardiovascular disease;
- Results from the following studies:
o The Data Collection on Adverse Events of Anti-Viral Drugs Study (D:A:D)
o Canadian HIV Vascular Study
o The San Francisco Ultrasound Study
o The Veterans Affairs Study

Bibliographic references :
Annika Rosengren, Steven Hawken, Stephanie Ôunpuu, Karen Sliwa, Mohammad Zubaid, Wael A Almahmeed, Kathleen Ngu Blackett, Chitr Sitthi-amorn, Hiroshi Sato, Salim Yusuf and for the INTERHEART investigatorsAssociation of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study The Lancet, Volume 364, Issue 9438, 11 September 2004-17 September 2004, Pages 953-962

Philip Greenland; Laurie LaBree; Stanley P. Azen; Terence M. Doherty; Robert C. DetranoCoronary Artery Calcium Score Combined With Framingham Score for Risk Prediction in Asymptomatic IndividualsJAMA, January 14, 2004; 291: 210 - 215

Priscilla Y. Hsue, Joan C. Lo, Arlana Franklin, Ann F. Bolger, Jeffrey N. Martin, Steven G. Deeks, and David D. WatersProgression of Atherosclerosis as Assessed by Carotid Intima-Media Thickness in Patients With HIV InfectionCirculation, Apr 2004; 109: 1603 - 1608.

   


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