CMEonHIV.com is dedicated to providing online CME presentations (slides with voiceover) on HIV/AIDS for healthcare professionals given by local and international experts to keep you up-to-date on the ongoing developments in the field.
Conference
"Intermediate Antiretroviral (ARV) Adherence Thresholds and the Development of Drug Resistance" Jesse Raffa (biography) English - 2006-05-26 - 19 minutes
(16 slides)
Summary : Adherence to antiretroviral treatment can substantially contribute to the rate of emergence of HIV drug resistance mutations. It’s been widely accepted that emergence of drug resistance is directly proportional to the patients level of adherence to treatment. Otherwise stated, it’s generally believed that an adherence nearing 100 percent precludes the risk of developing resistance mutations. A study by Raffa and colleagues sought to disprove this notion.
In this talk, the speaker presents data examining HIV plasma viral load, genotypic resistance histories, treatment, and adherence (measured via a surrogate methadone adherence). Patients were stratified by adherence levels below 80 percent, between 80 and 90 percent, and above 90 percent. The rate of accumulation of drug resistance was measured using multiple poisson regression model. The results of this study reveal an interesting adherence threshold important in the emergence of drug resistance.
Learning objectives : After viewing this presentation, participants will be able to discuss:
- Conventional belief in treatment adherence and the emergence of drug resistance;
- A study investigating specific adherence levels and the risk of drug resistance;
- Empirical models to predict drug resistance as a function of adherence.
USER ACKNOWLEDGES AND AGREES THAT ALL DECISIONS MADE WITH THE ASSISTANCE OR USE OF THE SOFTWARE AND/OR THE WEBSITE AND/OR BASED ON CONTENT FOUND HEREIN WILL BE EXCLUSIVELY THE RESPONSIBILITY OF THE USER.
