CMEonHIV.com is dedicated to providing online CME presentations (slides with voiceover) on HIV/AIDS for healthcare professionals given by local and international experts to keep you up-to-date on the ongoing developments in the field.
"Pathogenesis, presentation and management of IRIS" Prof. Martyn French (biography) English - 2008-02-06 - 38 minutes
Summary : In this presentation Prof. French discusses the pathogenesis of immune reconstitution inflammatory syndrome (IRIS) and its clinical management. He describes the concept of immune restoration disease (IRD) (1) and gives several examples of immunopathogenesis.
Among the topics covered is the potential occurrence of IRD in tuberculosis (TB) patients. According to available data, it is possible to make the distinction between a TB infection and an IRD after anti-retroviral therapy (ART).
Using immune markers, Crane et al. also tried to distinguish patients with hepatitis flares from those without. These markers were found to be increased with hepatitis flares, and to correlate with ALT levels. Being able to distinguish between the two phenomena could be useful in prevention and treatment. A review by Prof. French explores these perspectives (2).
Learning objectives : After viewing this presentation the participant will be able to discuss:
- Immune reconstitution inflammatory syndrome (IRIS)
- Pathogens that may provoke IRIS
- How to treat and prevent IRIS
- Recent data in this field
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