CMEonHIV.com is dedicated to providing online CME presentations (slides with voiceover) on HIV/AIDS for healthcare professionals given by local and international experts to keep you up-to-date on the ongoing developments in the field.
Conference
"Subtype C Isolates Rapidly Select for K65R Resistance with Tenofovir in Cell Culture" Dr. Bluma Brenner (biography) English - 2006-05-26 - 25 minutes
(15 slides)
Summary : In under a quarter of a century, the AIDS epidemic has surpassed malaria and tuberculosis worldwide and is considered the leading cause of death in developing countries. Though highly active antiretroviral therapy (HAART) is successful in stabilizing this epidemic, the beneficiaries of HAART treatment are primarily in the western world. Africa, East Asia, and Eastern Europe bear the brunt of poverty and other factors conducive to the epidemic. In addition to these health disparities there are also increasing variations of HIV strains. Prior to 1984, HIV subtype B predominated most endemic areas, with the exception of Ethiopia where subtype C was more prevalent. Since 1984, non-B subtypes expanded at an alarming rate necessitating further research to understand treatment responses of these subtypes. In an in vitro model, Brenner and colleagues examine the genotype and phenotype of resistant strains. In this study, clinical virus isolates of various subtypes were exposed to tenofovir to assess the rate of selection for the K65R mutation. Isolates with differential response rates were further examined for phenotypic similarities.
Learning objectives : After viewing this presentation, participants will be able to discuss:
- Epidemiology of HIV subtypes;
- Response to tenofovir in various HIV subtypes;
- Phenotypic profile among subtype variants.
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